ALTERED CELLULAR DISTRIBUTION AND SUB-CELLULAR SORTING OF DOPPEL (DPL) PROTEIN IN HUMAN ASTROCYTOMA CELL LINES

Altered Cellular Distribution and Sub-Cellular Sorting of Doppel (Dpl) Protein in Human Astrocytoma Cell Lines

Doppel, a prion-like protein, is a GPI-membrane anchored protein generally not expressed in the Central Nervous System (CNS) of different mammalian species, including human.Nevertheless, in astrocytomas, a particular kind of glial tumors, the doppel encoding gene (PRND) is over-expressed and the corresponding protein product (Dpl) is ectopically lo

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Initial Phylotranscriptomic Confirmation of Homoplastic Evolution of the Conspicuous Coloration and Bufoniform Morphology of Pumpkin-Toadlets in the Genus Brachycephalus

The genus Brachycephalus is a fascinating group of miniaturized anurans from the Brazilian Atlantic Forest, comprising the conspicuous, brightly colored pumpkin-toadlets and the cryptic flea-toads.Pumpkin-toadlets are known to contain tetrodotoxins and therefore, their bright colors may perform an aposematic function.Previous studies based on a lim

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